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Michael Crider
Southern Illinois University Edwardsville, USA

Somatostatin (SST) occurs in two biologically active forms SST-14 and a N-terminally-extended form SST-28. SST exerts its effects by binding to a family of G protein-coupled receptors designated sst1-sst5. Structure-activity studies have shown that the tetrapeptide fragment, Phe7-Trp8-Lys9-Thr10, comprises the critical ?-turn of SST. Although Phe7 and Thr10 can be modified, Trp8 and Lys9 are essential for biological activity. Since nonpeptide SST ligands offer therapeutic advantages over peptides, a screening program was initiated to identify a nonpeptide SST ligand with affinity for sst1-sst5. The search focused on the following: An aromatic moiety to mimic Phe7; a heteroaromatic nucleus to mimic Trp8, and a primary amine or other basic group to mimic Lys9. Using these search criteria, NNC 26-9100 was identified as the first sst4 agonist having high affinity (Ki=6 nM) and 100-fold sst4/sst2 selectivity at cloned human sst4 receptors. In a forskolin-induced cAMP assay, NNC 26-9100 potently inhibited cAMP accumulation and was shown to be a full agonist. NNC 26-9100 increased the expression of the enzyme neprilysin in the SAMP8 mouse model of Alzheimer’s disease. Neprilysin is the major A?-42 peptide degrading enzyme in the brain. Our studies demonstrate that NNC 26-9100 reduces A?-42 peptide levels in mouse cortex and that this reduction is associated with increased expression of neprilysin. Acute and chronic administration of NNC 26-9100 also increased learning and memory in SAMP8 mice using the T-maze test. These results suggest that NNC 26-9100 is a disease-modifying agent with potential use in the treatment of Alzheimer’s disease. Current studies in our laboratory are focused on the discovery on novel heterocyclic scaffolds with high affinity and selectivity at sst4 receptors. Image

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Delegates are personally responsible for their belongings at the venue. The Organizers will not be held responsible for any stolen or missing items belonging to Delegates, Speakers or Attendees; due to any reason whatsoever.


Registration fees do not include insurance of any kind.


Please note that any (or) all transportation and parking is the responsibility of the registrant.


Press permission must be obtained from Allied Academies Conferences Organizing Committee prior to the event. The press will not quote speakers or delegates unless they have obtained their approval in writing. The Allied Academies is an objective third-party nonprofit organization. This conference is not associated with any commercial meeting company.

Requesting an Invitation Letter

For security purposes, letter of invitation will be sent only to those individuals who had registered for the conference. Once your registration is complete, please contact to request a personalized letter of invitation.

Regarding refunds, all bank charges will be for the registrants account.

This cancellation policy was last updated on December 12, 2016.

Cancellation, Postponement and Transfer of Registration

All cancellations or modifications of registration must be made in writing to

Cancellation Policy

If Allied Academies cancels this event for any reason, you will receive a credit for 100% of the registration fee paid. You may use this credit for another Allied Academies event which must occur within one year from the date of cancellation.


If Allied Academies postpones an event for any reason and you are unable or unwilling to attend on rescheduled dates, you will receive a credit for 100% of the registration fee paid. You may use this credit for another Allied Academies event which must occur within one year from the date of postponement.

Transfer of registration

All fully paid registrations are transferable to other persons from the same organization, if registered person is unable to attend the event. Transfers must be made by the registered person in writing to . Details must be included the full name of replacement person, their title, contact phone number and email address. All other registration details will be assigned to the new person unless otherwise specified.

Registration can be transferred to one conference to another conference of Allied Academies if the person is unable to attend one of conferences.

However, Registration cannot be transferred if it is intimated within 14 days of respective conference.

The transferred registrations will not be eligible for Refund.

Visa Information

Keeping in view of increased security measures, we would like to request all the participants to apply for Visa as soon as possible.

Allied Academies will not directly contact embassies and consulates on behalf of visa applicants. All delegates or invitees should apply for Business Visa only.

Important note for failed visa applications: Visa issues cannot come under the consideration of cancellation policy of Allied Academies, including the inability to obtain a visa.

Refund Policy:

If the registrant is unable to attend, and is not in a position to transfer his/her participation to another person or event, then the following refund arrangements apply:

Keeping in view of advance payments towards Venue, Printing, Shipping, Hotels and other overheads, we had to keep Refund Policy is as following slabs-

  • Before 60 days of the conference: Eligible for Full Refund less $100 service Fee
  • Within 60-30 days of Conference: Eligible for 50% of payment Refund
  • Within 30 days of Conference: Not eligible for Refund
  • E-Poster Payments will not be refunded.

Accommodation Cancellation Policy:

Accommodation Providers (Hotels) have their own cancellation policies, and they generally apply when cancellations are made less than 30 days prior to arrival. Please contact us as soon as possible, if you wish to cancel or amend your accommodation. Allied Academies will advise the cancellation policy of your accommodation provider, prior to cancelling or amending your booking, to ensure you are fully aware of any non-refundable deposits.


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