Intracellular protein-protein interactions (PPIs) arise from biochemical events mediated by electrostatic forces, including the hydrophobic effect, are high-specific physical contacts between two or more protein molecules. These complexes of protein-protein interaction (PPI) may be regarded as a type of drug target. PPI targets vary from conventional drug targets consisting of a single protein, specifically an enzyme, whose activity is aimed at a chemical inhibitor reduction. Nevertheless, the flat and wide interacting surfaces of PPIs make them less appropriate for the enzyme design strategy of the traditional groove and ball inhibitor.
- Homo-oligomers vs. hetero-oligomers
- Stable interactions vs. transient interactions
- Covalent vs. non-covalent