Drug Toxicology

Drug Toxicity studies are primarily used to investigate specific adverse events and specific endpoints such as cancer, cardiotoxicity, and skin/eye irritation. Drug discovery is implied here to make a specialization drug of it. Patulin (PAT), a mycotoxin, is widespread in agricultural products. Although available research results suggest that PAT can be toxic to the nerves, immune system, and skin leading to heart, liver, and kidney damage. Trypan blue staining and Hoechst 33342 staining were used to analyze PAT, which induces apoptosis in 293 T cells. Superoxide dismutase (SOD), GSH, and malondialdehyde (MDA) were used to measure changes in the state Oxidative stress status of 293 T cells induced by PAT. Changes in reactive oxygen species (ROS) and ATP in mitochondria suggest a role for mitochondria when PAT induces cell damage and apoptosis. Through analysis of Cyt-C release assay, alteration of caspase activity, and correlation analysis, the potential mechanism of the mitochondrial apoptosis pathway was demonstrated. The results demonstrated that PAT induced cell damage significantly, and with increasing time and concentration, the cell survival rate decreased significantly. Hoechst 33342 staining and Trypan blue staining showed an increased rate of PAT-induced apoptosis. As PAT concentration increased, the activities of intracellular SOD and glutathione peroxidase decreased, and MDA content increased. Decreased intracellular ATP levels and accumulated ROS content suggest increased mitochondrial membrane permeability. Overexpression of Cyt-C triggered a cascade reaction of the enzyme caspase, leading to apoptosis. The results of the enzyme activity assay and correlation analysis indicated that caspase 3 was the most important in the cascade and was most correlated with caspase 8 and caspase 9. Drug discovery helps to make better medicinal components for this kind of effect.

  • Toxicogenomic
  • Apothecary
  • Immunotoxicology
  • Pesticide protection
  • Bioanalytical sciences

Mail us at

General Queries
Registration Queries
Exhibitor Queries
More details about sponsorship:sponsors@alliedacademies.com

Terms and Conditions


Delegates are personally responsible for their belongings at the venue. The Organizers will not be held responsible for any stolen or missing items belonging to Delegates, Speakers or Attendees; due to any reason whatsoever.


Registration fees do not include insurance of any kind.


Please note that any (or) all transportation and parking is the responsibility of the registrant.


Press permission must be obtained from Allied Academies Conferences Organizing Committee prior to the event. The press will not quote speakers or delegates unless they have obtained their approval in writing. The Allied Academies is an objective third-party nonprofit organization. This conference is not associated with any commercial meeting company.

Requesting an Invitation Letter

For security purposes, letter of invitation will be sent only to those individuals who had registered for the conference. Once your registration is complete, please contact drugdiscovery@alliedconferences.org to request a personalized letter of invitation.

Regarding refunds, all bank charges will be for the registrants account.

This cancellation policy was last updated on December 12, 2016.

Cancellation, Postponement and Transfer of Registration

All cancellations or modifications of registration must be made in writing to drugdiscovery@alliedconferences.org

Cancellation Policy

If Allied Academies cancels this event for any reason, you will receive a credit for 100% of the registration fee paid. You may use this credit for another Allied Academies event which must occur within one year from the date of cancellation.


If Allied Academies postpones an event for any reason and you are unable or unwilling to attend on rescheduled dates, you will receive a credit for 100% of the registration fee paid. You may use this credit for another Allied Academies event which must occur within one year from the date of postponement.

Transfer of registration

All fully paid registrations are transferable to other persons from the same organization, if registered person is unable to attend the event. Transfers must be made by the registered person in writing to drugdiscovery@alliedconferences.org . Details must be included the full name of replacement person, their title, contact phone number and email address. All other registration details will be assigned to the new person unless otherwise specified.

Registration can be transferred to one conference to another conference of Allied Academies if the person is unable to attend one of conferences.

However, Registration cannot be transferred if it is intimated within 14 days of respective conference.

The transferred registrations will not be eligible for Refund.

Visa Information

Keeping in view of increased security measures, we would like to request all the participants to apply for Visa as soon as possible.

Allied Academies will not directly contact embassies and consulates on behalf of visa applicants. All delegates or invitees should apply for Business Visa only.

Important note for failed visa applications: Visa issues cannot come under the consideration of cancellation policy of Allied Academies, including the inability to obtain a visa.

Refund Policy:

If the registrant is unable to attend, and is not in a position to transfer his/her participation to another person or event, then the following refund arrangements apply:

Keeping in view of advance payments towards Venue, Printing, Shipping, Hotels and other overheads, we had to keep Refund Policy is as following slabs-

  • Before 60 days of the conference: Eligible for Full Refund less $100 service Fee
  • Within 60-30 days of Conference: Eligible for 50% of payment Refund
  • Within 30 days of Conference: Not eligible for Refund
  • E-Poster Payments will not be refunded.

Accommodation Cancellation Policy:

Accommodation Providers (Hotels) have their own cancellation policies, and they generally apply when cancellations are made less than 30 days prior to arrival. Please contact us as soon as possible, if you wish to cancel or amend your accommodation. Allied Academies will advise the cancellation policy of your accommodation provider, prior to cancelling or amending your booking, to ensure you are fully aware of any non-refundable deposits.


Authorization Policy

Copyright © 2023-2024 Allied Academies, All Rights Reserved.